Use Of Daptomycin In Neonates: A Case Report And Review Of The Literature

We report a case of persistent bacteremia secondary to methicillin-resistant S. aureus (MRSA) in a preterm neonate successfully treated with daptomycin. Although the MRSA isolate was susceptible to vancomycin, there was no clinical or microbiologic response. Within 3 days of therapy with daptomycin, clinical improvement was noted, along with sterilization of blood cultures. Little data exist on neonatal pharmacokinetics of daptomycin. This report highlights the potential advantage that daptomycin offers in treating severe MRSA infections in neonates.