PS9 - 6. Cardiac microvascular perfusion defects precede insulin resistance in mildly obese mice

Obesity-induced microvascular dysfunction has been suggested to challenge myocardial function and perfusion, but the exact mechanism remains to be established. Here we studied the effects of mild obesity on basal and insulinmediated myocardial perfusion. In addition, as AMP-activated protein kinase (AMPK) determines eNOS activity and substrate metabolism in the myocardium 1 , we assessed AMPK activity in the myocardium of obese and lean mice.