A novel triterpene from Astraeus hygrometricus induces reactive oxygen species leading to death in Leishmania donovani.

Suvadip Mallick,Somaditya Dey,Supratim Mandal,Aritri Dutta,Debarati Mukherjee,Gunjan Biswas,Soumya Chatterjee,Tapan Kumar Lai,Krishnendu Acharya,Chiranjib Pal

Future microbiology（2015）

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摘要

We claim the present invention as substantial in depth evidences that mushroom derived active molecules can be exploited as target specific, comparatively nontoxic leads for antileishmanial therapy.

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关键词

Astraeus hygrometricus,Leishmania donovani,ROS,antileishmanial,apoptosis,mitochondrial dysfunction,mushroom,natural product,triterpene

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