Useful, regioflexible methods for functionalization of 1-phenylpyrrole derivatives
Tetrahedron(2012)
摘要
Highly regioselective mono-, di- and tribrominations of 1-[2-(trifluoromethyl)phenyl]-1H-pyrrole and several derivatives were accomplished with N-bromosuccinimide under mild conditions. Combined applications of these brominations with organometallic (e.g., bromine/lithium exchange or metalation) reactions provided a novel regioflexible route to new multifunctionalised 1-phenylpyrrole derivatives. The structures of the new products were determined by spectroscopic methods and confirmed in three cases with single crystal X-ray diffraction measurements.
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关键词
Regioselectivity,1-Phenylpyrrole,Carboxylic acid,Bromination,X-ray crystallography
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