Chiral 2-aminopyrimidin-4(1 H )-one derivative as the novel bifunctional organocatalyst: enantioselective Aldol reaction of isatins with ketones

Chiral 2-aminopyrimidin-4(1H)-one derivative 2 was discovered as a novel bifunctional organocatalyst for the asymmetric Aldol reaction of isatins with ketones. Wide substrate scopes were demonstrated with moderate to good yields (up to 92%) of desired Aldol products in high enantioselectivities (up to 94% ee).