Identifying patients infected with hepatitis B virus in sub-Saharan Africa: potential for misclassification

Diagnostic Microbiology and Infectious Disease(2015)

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摘要
Most research in sub-Saharan Africa establishes hepatitis B infection via one-time hepatitis B surface antigen (HBsAg) testing. Of 237 HIV-infected patients from two clinical trials testing HBsAg positive (MiniVidas®), 206 (86.9%) had validated serological tests using another assay (Architect). Discrepancies could be due to inactive infection, highlighting the importance of assessing hepatitis B virus infection phase.
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关键词
Hepatitis B virus,Isolated hepatitis B core antigen,Hepatitis surface antigen,Inactive hepatitis B infection,Bias
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