GPCR-Gs-mediated cyclic AMP signaling for neuritogenesis, growth arrest, and cell survival is parcellated among the cAMP sensors NCS/Rapgef2, Epac, and PKA (843.7)

Andrew C Emery,Maribeth Eiden,Tomris Mustafa,Lee E Eiden

The FASEB Journal（2014）

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摘要

Ligands that elevate cAMP through Gs-coupled GPCR activation have profound effects on the differentiation of neuroendocrine cells. Using the PC12 cell subclone NS-1, we found that cAMP-induced neur...

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关键词

camp sensors ncs/rapgef2,cell survival,cyclic amp,neuritogenesis

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