Lactose: a milk‐specific carbohydrate enabling homeostatic regulation of glucose and insulin (623.12)

Lactose, a disaccharide of glucose and galactose, is uniquely present in mammalian milk. Human milk provides the infant with about 40% energy as lactose and 50% from fat. With 6-7 g/dL lactose, the breast fed infant consumes high carbohydrate/kg body wgt, suggesting carbohydrate induced hepatic lipogenesis would be problematic with a high fat milk diet. However, galactose, unlike glucose is non-insulinogenic and shows high hepatic clearance. We propose lactose in human milk confers unique metabolic advantage to the infant by delivering non-insulinogenic carbohydrate which can be slowly metabolized in the liver to glucose or to support fatty acid oxidation. We determined insulin, glucose, triglyceride, free fatty acid and amino acid responses in 16 healthy adult men given in random order 650 mL carbohydrate-free infant formula reconstituted to contain 50g lactose, glucose, sucrose or corn syrup solids. The milk formula was given 3 hr after a lactose and sucrose-free meal, then again after 3 hr, to model th...