Plasticity Of The Human Plasma Lipidome Is Genetically Influenced And Associated With Type 2 Diabetes In Mexican American Families

Using Shannonu0027s entropy, we quantified the plasticity of the human plasma lipidome (defined as the extent to which the lipidome departs froma homeostatic equilibrium). Our objective was to test whether a) the plasticity is genetically influenced and b) whether it is associated with the presence of type 2 diabetes (T2D) in the high-risk population of Mexican Americans. We used data from 1,212 pedigreed individuals (representing 40 large and extended families) recruited in the San Antonio Family Heart Study. The plasma lipidome (318 lipid species, 22 classes) was measured using a combination of high-performance liquid chromatography and mass spectrometry. Using SOLAR software package and accounting for the kinship structure, we made three interesting observations: Lipid classMean EntropySD Entropyh2rp(h2r)s (T2D)p(T2D)Dihydroceramide2.340.090.281.87x10-110.030.6033Ceramide1.960.110.411.98x10-210.090.0972Monohexosylceramide2.120.050.323.27x10-100.070.2094Dihexosylceramide1.430.130.429.95x10-160.289.93x10-7Tr...