Crosstalk between purinergic receptors and canonical signaling pathways in the mouse salivary gland

Sumit Bhattacharya,John F Imbery, Prince Tuffour Ampem,David R Giovannucci

Cell Calcium（2015）

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摘要

•Crosstalk between β-AR and P2X4R potentiates [Ca2+]i signals in parotid acinar cells.•Crosstalk between β-AR and P2X7R enhances [Ca2+]i rises in parotid acinar cells.•Exocytotic release of ATP and activation of P2X7R enhances CCh evoked [Ca2+]i signals.

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关键词

Calcium signaling,Salivary gland,Purinergic receptor,Epac,cAMP,Parotid,Exocytosis,Crosstalk

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