Mitochondrial Ca2+ handling is crucial for generation of rhythmical Ca2+ waves in vascular interstitial cells from rabbit portal vein

Cell Calcium（2015）

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摘要

•The role of mitochondria in Ca2+ wave generation was studied in interstitial cells.•ATP synthase inhibitor, oligomycin, did not affect Ca2+ wave amplitude and frequency.•Uncoupling agents FCCP and CCCP blocked Ca2+ waves with simultaneous [Ca2+]i increase.

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关键词

Vasomotion,Vascular interstitial cell,Rhythmical calcium waves,Mitochondria

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