SIRT1 regulates accumulation of oxidized LDL in HUVEC via the autophagy-lysosomal pathway

Prostaglandins & Other Lipid Mediators(2016)

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摘要
•SIRT1 can decrease the accumulation of ox-LDL in HUVECs.•RSV increase the autophagic flux of HUVECs exposed to ox-LDL.•Inhibition of autophagy by Atg 5 siRNA and chloroquine inhibit the effect of SIRT1.
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关键词
SIRT1,ox-LDL,Accumulation,HUVECs,Autophagy-lysosomal pathway
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