Efficacy Of Dual Inhibition Of P38 Mitogen Activated Protein Kinase (Mapk) And Tie-2 Kinase In Myelodysplastic Syndromes (Mds) And Acute Myeloid Leukemia (Aml)

Introduction- MDS and AML are hematologic malignancies that are characterized by malignant cell expansion and suppression of normal hematopoietic activity. An inflammatory cytokine milieu in the marrow has been implicated in suppression of normal hematopoietic activity in MDS and AML. Since cytopenias are a major source of morbidity, these incurable diseases need agents that can target the malignant clones while also relieving the repression of healthy hematopoietic stem cells (HSCs) in the marrow. Angiopoietin -1 (Ang-1) is a cytokine that is implicated in vascular development and angiogenesis and has also been shown to regulate stem cell quiescence.