Reversal of the sleep–wake cycle by heroin self-administration in rats

Alissa A Coffey,Zhiwei Guan,Patricia Sue Grigson,Jidong Fang

Brain Research Bulletin（2016）

引用 15|浏览14

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摘要

•Heroin self-administration during the light cycle reverses the rat sleep–wake cycle.•Reversal does not depend on the amount of drug taken.•Wake and NREM sleep patterns recover immediately in abstinence.•REM sleep patterns remain reversed into early abstinence (3–6 days).

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关键词

Heroin,Self-administration,EEG,EMG,Sleep-wake,Circadian rhythm

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