Cytotoxic compounds from the fruits of Vitex rotundifolia against human cancer cell lines

Activity-guided fractionation of an ethanol extract from the fruits of Vitex rotundifolia led to the isolation of three flavonoids ( 1 – 3 ), one lignan ( 4 ), and three phenolic compounds ( 5 – 7 ). The structures of compounds 1 – 7 were identified by NMR data. The efficacy of all compounds was evaluated by their cytotoxic activities against nine human cancer cell lines using an in vitro assay.