Local treatment of the inner ear: A study of three different polymers aimed for middle ear administration

Cecilia Engmer Berglin,Pernilla Videhult Pierre,Andreas Ekborn,Tobias Bramer,Katarina Edsman,Malou Hultcrantz,Goran Laurell

Acta oto-laryngologica（2015）

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摘要

The results speak in favor of NaHYA, since it did not cause prolonged hearing threshold elevations. The results of the elimination and morphological investigations support the conclusion of NaHYA being the most promising candidate for intra-tympanic administration.

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关键词

ABR,carboxymethyl cellulose,guinea pig,hyaluronan,intra-tympanic,morphology,poloxamer 407,polymer,targeted drug delivery,toxicity

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