Identification of host cell factors involved in influenza A virus infection

As obligatory intracellular parasites, viruses need to take control of the metabolic pathways of the infected cells in order to complete their replication. Such an extraordinary ability must rely on specific, essential protein-protein interactions with key components of the cellular machinery. Besides providing valuable information about host-virus relationships, these studies can lead to the identification of novel pharmacological targets for an antiviral chemotherapeutic approach, based on the inhibition of host factors essential for viral replication. Here, we will review the most recent studies identifying host cell proteins involved in the influenza virus lifecycle.