Silica-induced inflammasome activation in macrophages: role of ATP and P2X7 receptor

Tatiana Luna-Gomes,Patricia Teixeira Santana,Robson Coutinho-Silva

Immunobiology（2015）

引用 44|浏览8

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摘要

•Overview of the current understanding and recent data on the role of ATP and P2X7 receptor in silica-induced inflammasome activation.•Inflammasome assembly in macrophages during silicosis: mechanisms of how silica particles are sensed by the NALP3 inflammasome.•Role of ATP in NLRP3 activation via P2X7 receptors.•Involvement of the P2X7 receptors in silica-induced NLRP3 activation.

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关键词

P2X7 receptor,ATP,Inflammasome,Interleukin 1β,Silica,NLRP3

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