Truncated somatostatin receptor 5 may modulate therapy response to somatostatin analogues — Observations in two patients with acromegaly and severe headache

D Marina,Pia Burman,Marianne Klose,Olivera Casarborota, Raul M Luque,Justo P Castano,Ulla Feldtrasmussen

Growth Hormone & IGF Research（2015）

引用 22|浏览9

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摘要

•Treatment of acromegaly is based on surgery or/and somatostatin analogues.•We examined expression of somatostatin receptors 1–5 in two acromegaly patients.•Highly expressed truncated receptor 5 (sst5TMD4) influenced treatment result.•Sst5TMD4 has dominant-negative effect on somatostatin receptor 2 signaling pathways.

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关键词

Acromegaly,Pasireotide,Headache,Analgesic effect,Somatostatin receptors,Truncated sst5

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