Up-regulation of Cathepsin G in the Development of Chronic Postsurgical Pain: An Experimental and Clinical Genetic Study.

Xiaodong Liu,Yuanyuan Tian,Zhaoyu Meng, Yan Chen,Idy H T Ho,Kwong Wai Choy, Peter Lichtner,Sunny H Wong,Jun Yu,Tony Gin,William K K Wu,Christopher H K Cheng,Matthew T V Chan

Anesthesiology（2015）

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摘要

This study demonstrated that CTSG is a pronociceptive mediator in both animal model and human study. CTSG represents a new target for pain control and a potential marker to predict patients who are prone to develop chronic pain after surgery.

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