202 Bone mineral density and fractures at the All Wales Adult CF Centre (AWACFC)

CF related low bone mineral density (CFRLBMD) occurs in 34% CF patients (Haworth 2001). 14% of CF patients have evidence of vertebral fractures and 20% nonvertebral fractures (Paccou 2010). Aim To determine the prevalence of CFLBMD and fractures in patients attending the AWACFC. Method The following information taken from the annual reviews of patients attending the AWACFC: age, sex, history and nature of fractures, FEV 1 %, BMI, Z score Lumbar spine (LS) and hip and whether the patient was maintained on calcium/vitamin D and bisphosphonate, duration of bisphosphonate use and change in Z score over this period. Patients completed a fracture history questionnaire. Results 254 (144 male) patients were included with a mean (SD) age, FEV 1 % and BMI of 28.8 (9.4) years, 65.7% (25.6) and 22.8 kg/m 2 (4.65) respectively. Their median (range) Z score at lumbar spine (LS) and hip were –0.87 (–4.2 to 2.4) and –0.64 (–3.7 to 2.6) respectively. 57 (32 male) of 254 (22%) patients had CFRLBMD. Of these 57, 55 (96%) were on calcium/vit D and 44 (77%) on bisphosphonate therapy. Patients with CFRLBMD had lower FEV 1 % [47.5 vs 70.7 (p 2 (p Conclusion The prevalence of CFRLBMD at the AWACFC is slightly lower than Haworth study which may reflect a trend to a more aggressive approach to CF therapies over the past decade. The prevalence of fractures in our cohort is similar to other studies.