Organophosphate Exposure: Detection And Remediation

Organophosphate (OP) exposure continues to be a threat to both civilian and military personnel. Sensitive and specific methods for the detection and remediation are needed not only for public health but also for farmers who are exposed to OPs frequently. Although detection approaches based on a mass spectrometry are sensitive and reliable, they require expensive equipment and expert operators. In addition, instrumentation such as mass spectrometer cannot be easily deployed in the field. Attempts to make point-of-care approaches have been the trend in both detecting and rescuing OP exposure in the current research of OP toxicity. This chapter will discuss some recent progress reported concerning the immunodetection of OP exposure and improved antidote therapy in the remediation of OP exposure.