Synthesis of a 5-azaindole phosphonic acid as a computationally designed inhibitor of the low molecular weight phosphatase HCPTP

Weitgenant Jeremy A., Katsuyama Isamu, Bigi Marinus A.,Corden Steven J.,Markiewicz John T.,Zabell Adam P. R.,Homan Kristoff T.,Wiest Olaf,Stauffacher Cynthia V.,Helquist Paul

Heterocycles（2006）

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摘要

A computationally designed inhibitor of human low molecular weight protein tyrosine phosphatase, HCPTP, was synthesized. The target compound is based on a 5-azaindole heterocyclic core bearing a phosphonic acid side chain. Its synthesis was accomplished in ten steps.

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关键词

azaindole,phosphatase inhibitor,diphosphonate condensation

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