327 Ischemic Heart Disease in Metis in Manitoba: Results From the Ischemic Heart Disease and Related Health Care Utilization Study

less likely to be on OMT at baseline, [aspirin (74% vs. 94%), s-blockers (63% vs. 83%) and ACE inhibitors (76% vs. 83%), p 0.03 for all]. The use of insulin was higher in the registry patients (40% vs. 20% p 0.049) and fewer received metformin (50% vs. 77% p 0.007) compared to the enrolled patients. A fewer number of registry patients underwent revascularization (10 vs. 22). The 5-year lipid profile and HbA1c levels were similar for both groups. The composite of death, MI, stroke and revascularization was similar (46%), see Table 1 below. Individually the registry patients had lower incidence of MI and a significantly higher mortality compared to the enrolled patients. Patients in both groups who declined surgical revascularization had the highest mortality rate (36%). CONCLUSION: Significantly different outcomes were observed in registry and enrolled patients. Unlike prior observations mortality was substantially higher in the registry cohort compared to the trial cohort. These results further support the need for large concomitant registry cohort during RCTs testing strategies with the aim that the generalisability of new interventions can be better informed.