Evaluation for a mutagenicity of aristolochic acid by Pig-a and PIGRET assays in rats

Naomi Koyama, Yutaka Yonezawa,Michi Nakamura,Hisakazu Sanada

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2016）

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摘要

•We examined the mutagenicity of AA using the RBC Pig-a assay and the PIGRET assay.•AA induced Pig-a mutant RBCs and RETs in rats.•The PIGRET assay could detect Pig-a mutants by AA more quickly.

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关键词

Aristolochic acid,RBC Pig-a assay,PIGRET assay

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