Combination comet/micronucleus assay validation performed by BioReliance under the JaCVAM initiative

Kamala Pant,Ljubica Krsmanovic,Shannon W Bruce, Tawney Kelley,Mirna Arevalo, Samuel Attasafoh, Fekadu Debelie, Michelle L Klug La Force,Sandra A Springer,Jamie E Sly,Madhav G Paranjpe,Timothy E Lawlor,Marilyn J Aardema

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2015）

引用 7|浏览25

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摘要

•This paper describes comet validation at BioReliance under the JaCVAM initiative.•Three chemicals were tested, 1,3-dichloropropene, ethionamide and busulfan.•1,3-Dichoropropene was positive in comet assay and negative in micronucleus assay.•Ethionamide was negative in both comet and micronucleus assays.•Busulfan was negative in comet assay and positive in micronucleus assay.

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In vivo comet assay,JaCVAM validation study,1,3-Dichloropropene,Ethionamide,Busulfan,In vivo micronucleus (MN) assay,Combination comet/MN assay

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