Genetic alterations in periprosthetic soft-tissue masses from patients with metal-on-metal hip replacement

Virinder Kaur Sarhadi,Jyrki Parkkinen,Aleksi Reito,Jyrki Nieminen,Noora Porkka, Tiina Wirtanen,Minna Laitinen,Antti Eskelinen,Sakari Knuutila

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis（2015）

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摘要

•Periprosthetic tissues from patients with hip replacements show genetic alterations.•Gains of JAK2, INSL6 at 9q24.1 and RUNX2 at 6p21.1 seen in periprosthetic tissues.•Mutations in NOTCH1 seen in periprosthetic tissues.•Genetic alterations are associated with longer in-situ time of the implant.

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关键词

Periprosthetic tissue,Hip replacement,Pseudotumor,Mutations,aCGH,Metal-on-metal implant

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