Efficient Synthesis Of Novel Thiazol-2-Ylidene-Amides Using Carbonylthiourea Building Blocks

In this work, an efficient and versatile synthesis of novel thiazol-2-ylidene-amides from various carbonylthiourea derivatives is described. A sequential alkylation-cyclization reaction between thioureas and propargyl bromide in the presence of DABCO in refluxing ethanol afforded 4-methylthiazol-2(3H)-ylidene-amide derivatives in good yields.