Zinc(II)cyclen–peptide conjugates interacting with the weak effector binding state of Ras

Zinc(II)cyclen based compounds were synthesized and investigated by NMR as potential inhibitors of Ras-effector interaction to interrupt Ras induced signal transduction. Representing an important molecular switch in cells whose dysfunction was found to be closely related with certain types of cancer, recapturing the control of mutated Ras is of high interest.