BET inhibitor resistance emerges from leukaemia stem cells
NATURE(2015)
摘要
BET inhibitors that target bromodomain chromatin readers such as BRD4 are being explored as potential therapeutics in cancer; here, in a MLL–AF9 mouse leukaemia model, resistance to BET inhibitors is shown to emerge from leukaemia stem cells, and be partly due to increased Wnt/β-catenin signalling.
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关键词
chromatin,epigenetics
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