Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching

Junchao Dong,Rohit A. Panchakshari,Tingting Zhang,Yu Zhang,Jiazhi Hu,Sabrina A. Volpi,Robin M. Meyers,Yu-Jui Ho,Zhou Du,Davide F. Robbiani,Feilong Meng,Monica Gostissa,Michel C. Nussenzweig,John P. Manis,Frederick W. Alt

NATURE（2015）

引用 107|浏览46

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摘要

High-throughput genome-wide sequencing reveals why class switch recombination in the IgH locus, an essential step in the process of antibody generation, has a directional joining bias towards deletion rather than inversion.

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关键词

B cells,Double-strand DNA breaks,Science,Humanities and Social Sciences,multidisciplinary

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