Marfan Syndrome Exon CpG Percentage and Fractal Dimension

The CpG di-nucleotide percentage and exon fractal dimension fluctuation were investigated with respect to the recently identified Marfan syndrome exons in the FBN1 gene. The CpG di-nucleotide percentage was found to rank high in exon 1 (9%), exon 44 (6.5%), exon 24 (5.3%) and exon 27 (4.8%). The most significant Marfan exon group was reported to be exon 24- 32. An exon nucleotide sequence can be expressed as a numerical sequence when each nucleotide is assigned its proton number. The resulting exon nucleotide numerical sequence could be investigated for its fractal dimension. The fractal dimension exhibited fluctuation across the 65 FBN1 exons and the values formed a Gaussian-like distribution (N = 65). The moving average fractal dimension was found to exhibit a broad peak around exons 24 to 32, consistent with the reported Marfan syndrome exon group.