CaMKIIα Knockdown Decreases Anxiety in the Open Field and Low Serotonin-Induced Upregulation of GluA1 in the Basolateral Amygdala.

Behavioural Brain Research（2016）

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摘要

•Low serotonin (5-HT) increased anxiety and glutamate receptor (GluA1) expression.•Depletion of 5-HT in the basolateral amygdala (BLA) increased CaMKII activation.•CaMKII activation correlated with anxiety and GluA1 expression.•Knockdown of CaMKII in the BLA attenuated anxiety and decreased GluA1 expression.

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关键词

5-HT,AAV,amygdala,CaMKII,Glutamate,Immunoblot,RNAi,RT-PCR

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