Predicting nsSNPs the disrupt protein-protein interactions using docking.

Norman Goodacre,Nathan Edwards,Mark Danielsen,Peter Uetz,Cathy Wu

IEEE/ACM Transactions on Computational Biology and Bioinformatics（2017）

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摘要

The human genome contains a large number of protein polymorphisms due to individual genome variation. How many of these polymorphisms lead to altered protein-protein interaction is unknown. We have developed a method to address this question. The intersection of the SKEMPI database (of affinity constants among interacting proteins) and CAPRI 4.0 docking benchmark was docked using HADDOCK, leading ...

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Proteins,Predictive models,Databases,Training,Kinetic theory,Human immunodeficiency virus

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