Selectivity of C3-opsonin targeted complement inhibitors: A distinct advantage in the protection of erythrocytes from paroxysmal nocturnal hemoglobinuria patients

Christoph Q. Schmidt,Markus J. Harder,Eva-Maria Nichols,Mario Hebecker,Markus Anliker,Britta Höchsmann,Thomas Simmet,Ádám I. Csincsi,Barbara Uzonyi,Isabel Y. Pappworth,Daniel Ricklin,John D. Lambris,Hubert Schrezenmeier,Mihály Józsi,Kevin J. Marchbank

Immunobiology（2016）

引用 23|浏览11

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摘要

•Complement inhibitor miniFH protects PNH erythrocytes more efficiently than FH-CR2.•Contrary to eculizumab, miniFH and FH-CR2 act more selectively on host cells.•C3-opsonin targeted inhibitors largely maintain bactericidal serum activity in vitro.

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关键词

Complement targeted inhibition,Paroxysmal nocturnal hemoglobinuria,Alternative pathway,miniFH

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