Extreme dNTP pool changes and hypermutability in dcd ndk strains

Lawrence Tse,Tina Manzhu Kang,Jessica Yuan,Danielle Mihora,Elinne Becket,Katarzyna H. Maslowska,Roel M. Schaaper,Jeffrey H. Miller

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis（2016）

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摘要

•Imbalances in the normal dNTP pools lead to increased mutagenesis.•E. coli mutants lacking both DCD and NDK have extreme imbalances of dNTPs.•Mutants lacking both DCD and NDK have exceptionally high mutation levels.

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关键词

Hypermutability,dNTP pools,dcd ndk mutant

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