Impact of CYP2C19 genetic polymorphisms on voriconazole dosing and exposure in adult patients with invasive fungal infections.

Fabien Lamoureux,Thomas Duflot,Jean-Baptiste Woillard,David Metsu,Tony Pereira,Patricia Compagnon,Hélène Morisse-Pradier, Mona El Kholy,Luc Thiberville,Jana Stojanova,Christian Thuillez

International Journal of Antimicrobial Agents（2016）

引用 78|浏览21

暂无评分

摘要

•Subtherapeutic voriconazole (VCZ) concentrations are common in clinical practice.•The CYP2C19*17 allele is associated with increased VCZ metabolism.•VCZ doses to achieve target levels are higher in CYP2C19*17 carriers.•CYP2C19 genotyping can predict VCZ exposure/dose to achieve effective levels.

查看译文

关键词

Voriconazole,Pharmacogenomics,CYP2C19,Antifungals,Drug monitoring

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要