Phosphorylation Of 4ebp By Oral Leucine Administration Was Suppressed In The Skeletal Muscle Of Pgc-1 Alpha Knockout Mice

Ryoji Yoshimura,Kimiko Minami,Junichiro Matsuda,Naoki Sawada,Shinji Miura,Yasutomi Kamei

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY（2016）

引用 7|浏览7

暂无评分

摘要

Leucine is known to increase mTOR-mediated phosphorylation of 4EBP. In this study, leucine was administered to skeletal muscle-PGC-1 knockout mice. We observed attenuated 4EBP phosphorylation in the skeletal muscle, but not in the liver, of the PGC-1 knockout mice. These data suggest that skeletal muscle-PGC-1 is important for leucine-mediated mTOR activation and protein biosynthesis.

查看译文

关键词

leucine, muscle specific PGC-1 knockout mouse, 4EBP, mTOR

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要