Renal Cell Carcinoma Programmed Death-ligand 1, a New Direct Target of Hypoxia-inducible Factor-2 Alpha, is Regulated by von Hippel-Lindau Gene Mutation Status.

Yosra Messai,Sophie Gad,Muhammad Zaeem Noman,Gwenael Le Teuff,Sophie Couve,Bassam Janji, Solenne Florence Kammerer,Nathalie Rioux-Leclerc,Meriem Hasmim,Sophie Ferlicot,Véronique Baud,Arnaud Mejean,David Robert Mole,Stéphane Richard,Alexander M M Eggermont,Laurence Albiges,Fathia Mami-Chouaib,Bernard Escudier,Salem Chouaib

European Urology（2016）

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摘要

In the present study, we investigated the relationship between von Hippel–Lindau (VHL) mutations and programmed death-ligand 1 (PD-L1) expression. We demonstrated that VHL mutation status significantly correlated with PD-L1 expression in clear cell renal cell carcinoma patients. We also demonstrated that VHL mutations induced hypoxia-inducible factor-2 alpha stabilization that positively regulates PD-L1 expression.

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关键词

ccRCC,VHL mutations,HIF-2α,PD-L1

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