In cellulo phosphorylation of XRCC4 Ser320 by DNA-PK induced by DNA damage.

Mukesh Kumar Sharma,Shoji Imamichi,Mikoto Fukuchi,Ravindra Mahadeo Samarth,Masanori Tomita,Yoshihisa Matsumoto

Journal of Radiation Research（2016）

引用 13|浏览6

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摘要

XRCC4 is a protein associated with DNA Ligase IV, which is thought to join two DNA ends at the final step of DNA double-strand break repair through non-homologous end joining. In response to treatment with ionizing radiation or DNA damaging agents, XRCC4 undergoes DNA-PK-dependent phosphorylation. Furthermore, Ser260 and Ser320 (or Ser318 in alternatively spliced form) of XRCC4 were identified as ...

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关键词

DNA double-strand break repair,non-homologous end joining (NHEJ),DNA-dependent protein kinase (DNA-PK),XRCC4,phosphorylation

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