Surface modification of PLGA nanoparticles with biotinylated chitosan for the sustained in vitro release and the enhanced cytotoxicity of epirubicin.

Hongli Chen,Li Qin Xie,Jingwen Qin,Yajing Jia,Xinhua Cai,WenBin Nan,Wancai Yang,Feng Lv,Qi Qing Zhang

Colloids and Surfaces B: Biointerfaces（2016）

引用 81|浏览13

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摘要

•We successfully prepared Bio-CS-PLGA NPs with active functional group of biotin on their surface.•Bio-CS-PLGA NPs exhibited a greater extent of cellular uptake.•Bio-CS-PLGA NPs were able to enter into cancer cells via biotin receptor endocytosis.•Bio-CS-PLGA NPs were mainly distributed in the tumor after 24h post administration.

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关键词

PLGA nanoparticle,Chitosan,Biotin,Epbrubicin

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