Antibody-coupled siRNA as an efficient method for in vivo mRNA knockdown

Nicole Bäumer,Neele Appel, Lisa Terheyden,Frank Buchholz,Claudia Rossig,Carsten Müller-Tidow,Wolfgang E Berdel,Sebastian Bäumer

NATURE PROTOCOLS（2015）

引用 41|浏览33

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摘要

This virus-free approach for mRNA knockdown in vivo uses the siRNA carrier peptide protamine, chemically coupled to a cell surface receptor internalizing antibodies via sulfo-SMCC, to provide protection and guidance for the targeted application of siRNA.

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关键词

chemical modification,rnai

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