In Vivo Gene-Silencing in Fibrotic Liver by siRNA-Loaded Cationic Nanohydrogel Particles.

Leonard Kaps,Lutz Nuhn,Misbah Aslam,Alexander Brose,Friedrich Foerster,Sebastian Rosigkeit,Patricia Renz,Rosario Heck,Yong Ook Kim,Ingo Lieberwirth,Detlef Schuppan,Rudolf Zentel

ADVANCED HEALTHCARE MATERIALS（2015）

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摘要

Cationic nanohydrogel particles loaded with anti-Col1α1 siRNA suppress collagen synthesis and deposition in fibrotic mice: Systemically administered 40 nm sized nanogel particles accumulate in collagen-expressing cells in the liver. Their siRNA payload induces a sequence specific in vivo gene knockdown affording an efficient antifibrotic effect in mice with liver fibrosis.

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关键词

cationic nanohydrogels,in vivo gene knockdown,liver fibrosis,nanogels,siRNA delivery

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