Pre-menstrual flares of pyoderma gangrenosum controlled with use of a combined oral contraceptive and antiandrogen (Ethinyl Estradiol/Drospirenone).

The effect of sex hormones on pyoderma gangrenosum (PG) has not been reported. We report the case of a 34-year-old woman with chronic PG leg ulcers who was found to have recurring, premenstrual flares of PG. Her PG flares were controlled with the use of ethinyl estradiol/drospirenone.