The noncoding RNAs SNORD50A and SNORD50B bind K-Ras and are recurrently deleted in human cancer

Zurab Siprashvili,Dan E Webster,Danielle Johnston,Rajani M Shenoy,Alexander J Ungewickell,Aparna Bhaduri,Ross Flockhart,Brian J Zarnegar,Yonglu Che, Francesca Meschi,Joseph D Puglisi,Paul A Khavari

NATURE GENETICS（2015）

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摘要

Paul Khavari and colleagues analyze tumor genomes to identify snoRNAs showing frequent copy number loss of adjacently encoded snoRNAs SNORD50A and SNORD50B. These snoRNAs directly bound K-Ras and their loss leads to increased activity of both wild-type and oncogenic K-Ras and is associated with reduced survival.

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cancer,gene regulation

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