"Fit-for-purpose" development of analytical and (semi)preparative enantioselective high performance liquid and supercritical fluid chromatography for the access to a novel σ1 receptor agonist.

Daniela Rossi,Annamaria Marra,Marta Rui,Stefania Brambilla,Markus Juza,Simona Collina

Journal of Pharmaceutical and Biomedical Analysis（2016）

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摘要

•Efficient screening for enantioselective analytical and semi-preparative HPLC and SFC results in methods “fit-for-purpose”.•Analytical enantiomer separation of (R/S)-2-(4-phenylphenyl)-4-(1-piperidyl)butan-2-ol by HPLC or SFC.•Successful scale-up in enantioselective HPLC and SFC resulting in sufficient amounts for determination of chirooptical properties and assignment of absolute configuration in less than two weeks.•Selection of elution order for the enantiomers possible.

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关键词

Amylose and cellulose derived CSPs,Chiral resolution,Elution order,Enantioselective HPLC and SFC,Sigma 1 (σ1) receptor agonist

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&quot;Fit-for-purpose&quot; development of analytical and (semi)preparative enantioselective high performance liquid and supercritical fluid chromatography for the access to a novel σ1 receptor agonist.

"Fit-for-purpose" development of analytical and (semi)preparative enantioselective high performance liquid and supercritical fluid chromatography for the access to a novel σ1 receptor agonist.