HVR1-mediated antibody evasion of highly infectious in vivo adapted HCV in humanised mice

    Gut, 2015.

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    Keywords:
    HCVHEPATITIS C

    Abstract:

    HCV is a major cause of chronic liver disease worldwide, but the role of neutralising antibodies (nAbs) in its natural history remains poorly defined. We analysed the in vivo role of hypervariable region 1 (HVR1) for HCV virion properties, including nAb susceptibility.Analysis of HCV from human liver chimeric mice infected with cell-cultu...More

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