Polyalanine expansions drive a shift into α-helical clusters without amyloid-fibril formation
NATURE STRUCTURAL & MOLECULAR BIOLOGY(2015)
摘要
In vitro and in vivo analyses show that the aggregation mechanism of polyalanine expansions is based on assembly into α-helical clusters with diverse oligomeric species, in contrast to that of polyglutamine expansions, which form amyloid fibrils.
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关键词
Cellular imaging,Protein aggregation,Life Sciences,general,Biochemistry,Protein Structure,Membrane Biology,Biological Microscopy
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