Neuromuscular Blocking Agent Cisatracurium Attenuates Lung Injury by Inhibition of Nicotinic Acetylcholine Receptor-α1

ANESTHESIOLOGY, pp. 132-140, 2015.

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Keywords:
attenuationinterleukin 6

Abstract:

Background: Neuromuscular blocking agents (NMBAs) bind the nicotinic acetylcholine receptor alpha 1 (nAChR alpha 1) that also contributes to inflammatory signaling. Thus, the author hypothesized that the use of NMBA mitigates lung injury by improving ventilator synchrony and decreasing inflammatory responses. Methods: Lung injury was indu...More

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