Sevoflurane postconditioning improves long-term learning and memory of neonatal hypoxia-ischemia brain damage rats via the PI3K/Akt-mPTP pathway.

Zhongmeng Lai,Liangcheng Zhang, Jiansheng Su,Dongmiao Cai,Qingxiu Xu

Brain Research（2016）

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摘要

•Sevoflurane postconditioning protects against hypoxia-ischemia brain damage in rats.•Postconditioning significantly improved long-term cognitive performance of the rats.•Postconditioning increased the number of surviving hippocampal neurons.•The effects of sevoflurane are via PI3K/Akt/eNOS and PI3K/Akt/GSK-3β pathways.•Blockage of mPTP opening may be involved in attenuation of histomorphological injury.

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关键词

HIBD,mPTP,eNOS,mPTP,Atr,CsA,TTC,Sev,EL,HE,BSA,SD,LSD,PCA

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